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Can I delete the entries in the "profile - cache" folder?

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Using Windows XP and Thunderbird 38.0.1 (portable edition). In the folder, "Data -> profile ->" there are two subfolders named "cache" and "cache.trash3362" which seem to have grown to such an extent that they have caused Thunderbird to load very slowly. Can I empty those folders without any ill effects?

Using Windows XP and Thunderbird 38.0.1 (portable edition). In the folder, "Data -> profile ->" there are two subfolders named "cache" and "cache.trash3362" which seem to have grown to such an extent that they have caused Thunderbird to load very slowly. Can I empty those folders without any ill effects?

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On the toolbar > Options> Advanced > Network and disk space press clear now.