That error message suggests that the SMTP server you are using won't accept email messages with a from: address that is related to some other domain.

Have you set your account to use the emailsrvr smtp server?

I have set my account to use the emailsrvr smtp server

Did you remove the old SMTP server info?

I removed the old SMTP server info. I changed to secure.emailsrvr.com and still cannot send.

Go to the Help Menu. Click Troubleshooting Information. Then Copy to Clipboard. Come back here and paste that into a reply window.

Application Basics

   Name: Thunderbird
   Version: 52.1.0
   User Agent: Mozilla/5.0 (Windows NT 6.1; WOW64; rv:52.0) Gecko/20100101 Thunderbird/52.1.0
   Profile Folder: Open Folder

             (Local drive)
   Application Build ID: 20170428151619
   Enabled Plugins: about:plugins
   Build Configuration: about:buildconfig
   Memory Use: about:memory
   Profiles: about:profiles

 Mail and News Accounts
   account1:
     INCOMING: account1, , (none) Local Folders, plain, passwordCleartext

   account2:
     INCOMING: account2, , (pop3) pop.att.yahoo.com:995, SSL, passwordCleartext
     OUTGOING: , smtp.att.yahoo.com:465, SSL, passwordCleartext, true

   account3:
     INCOMING: account3, , (pop3) secure.emailsrvr.com:995, SSL, passwordCleartext
     OUTGOING: , secure.emailsrvr.com:465, SSL, passwordCleartext, true

   account6:
     INCOMING: account6, , (pop3) pop.att.yahoo.com:995, SSL, passwordCleartext
     OUTGOING: , smtp.att.yahoo.com:465, SSL, passwordCleartext, true

   account7:
     INCOMING: account7, , (pop3) pop.att.yahoo.com:995, SSL, passwordCleartext
     OUTGOING: , smtp.att.yahoo.com:465, SSL, passwordCleartext, true

   account8:
     INCOMING: account8, , (pop3) secure.emailsrvr.com:995, SSL, passwordCleartext
     OUTGOING: , secure.emailsrvr.com:465, SSL, passwordCleartext, true

   account11:
     INCOMING: account11, , (pop3) secure.emailsrvr.com:995, SSL, passwordCleartext
     OUTGOING: , secure.emailsrvr.com:465, SSL, passwordCleartext, true

   account12:
     INCOMING: account12, , (imap) imap.gmail.com:993, SSL, OAuth2
     OUTGOING: , smtp.gmail.com:465, SSL, OAuth2, true

   account13:
     INCOMING: account13, , (pop3) pop.emailsrvr.com:110, alwaysSTARTTLS, passwordCleartext
     OUTGOING: , secure.emailsrvr.com:465, SSL, passwordCleartext, true

 Crash Reports
   https://crash-stats.mozilla.com/report/index/bp-84fbdc10-36eb-49d4-a02c-208a42161104 (11/3/2016)

 Extensions
   Lightning, 5.4.1, true, {e2fda1a4-762b-4020-b5ad-a41df1933103}

 Important Modified Preferences

   Name: Value

     browser.cache.disk.capacity: 358400
     browser.cache.disk.filesystem_reported: 1
     browser.cache.disk.smart_size_cached_value: 358400
     browser.cache.disk.smart_size.first_run: false
     browser.cache.disk.smart_size.use_old_max: false
     dom.apps.reset-permissions: true
     extensions.lastAppVersion: 52.1.0
     font.internaluseonly.changed: false
     font.name.monospace.el: Consolas
     font.name.monospace.tr: Consolas
     font.name.monospace.x-baltic: Consolas
     font.name.monospace.x-central-euro: Consolas
     font.name.monospace.x-cyrillic: Consolas
     font.name.monospace.x-unicode: Consolas
     font.name.monospace.x-western: Consolas
     font.name.sans-serif.el: Calibri
     font.name.sans-serif.tr: Calibri
     font.name.sans-serif.x-baltic: Calibri
     font.name.sans-serif.x-central-euro: Calibri
     font.name.sans-serif.x-cyrillic: Calibri
     font.name.sans-serif.x-unicode: Calibri
     font.name.sans-serif.x-western: Calibri
     font.name.serif.el: Cambria
     font.name.serif.tr: Cambria
     font.name.serif.x-baltic: Cambria
     font.name.serif.x-central-euro: Cambria
     font.name.serif.x-cyrillic: Cambria
     font.name.serif.x-unicode: Cambria
     font.name.serif.x-western: Maiandra GD
     font.size.fixed.el: 14
     font.size.fixed.tr: 14
     font.size.fixed.x-baltic: 14
     font.size.fixed.x-central-euro: 14
     font.size.fixed.x-cyrillic: 14
     font.size.fixed.x-unicode: 14
     font.size.fixed.x-western: 14
     font.size.variable.el: 17
     font.size.variable.tr: 17
     font.size.variable.x-baltic: 17
     font.size.variable.x-central-euro: 17
     font.size.variable.x-cyrillic: 17
     font.size.variable.x-unicode: 17
     font.size.variable.x-western: 14
     mail.openMessageBehavior.version: 1
     mail.winsearch.firstRunDone: true
     mailnews.database.global.datastore.id: 22a1a6f8-e230-42cb-a3ea-4c21173a72d
     mailnews.database.global.views.conversation.columns: {"threadCol":{"visible":true,"ordinal":"1"},"flaggedCol":{"visible":true,"ordinal":"3"},"attachmentCol":{"visible":false…
     media.gmp.storage.version.observed: 1
     network.cookie.cookieBehavior: 3
     network.cookie.prefsMigrated: true
     network.predictor.cleaned-up: true
     places.database.lastMaintenance: 1493308622
     places.history.expiration.transient_current_max_pages: 122334
     plugin.importedState: true
     plugins.update.notifyUser: true
     print.print_printer: CutePDF Writer

Part 2 of the Troubleshoot Info

print.printer_CutePDF_Writer.print_bgcolor: false

     print.printer_CutePDF_Writer.print_bgimages: false
     print.printer_CutePDF_Writer.print_colorspace:
     print.printer_CutePDF_Writer.print_command:
     print.printer_CutePDF_Writer.print_downloadfonts: false
     print.printer_CutePDF_Writer.print_duplex: 63104
     print.printer_CutePDF_Writer.print_edge_bottom: 0
     print.printer_CutePDF_Writer.print_edge_left: 0
     print.printer_CutePDF_Writer.print_edge_right: 0
     print.printer_CutePDF_Writer.print_edge_top: 0
     print.printer_CutePDF_Writer.print_evenpages: true
     print.printer_CutePDF_Writer.print_footercenter:
     print.printer_CutePDF_Writer.print_footerleft: &PT
     print.printer_CutePDF_Writer.print_footerright: &D
     print.printer_CutePDF_Writer.print_headercenter:
     print.printer_CutePDF_Writer.print_headerleft: &T
     print.printer_CutePDF_Writer.print_headerright: &U
     print.printer_CutePDF_Writer.print_in_color: true
     print.printer_CutePDF_Writer.print_margin_bottom: 0.5
     print.printer_CutePDF_Writer.print_margin_left: 0.5
     print.printer_CutePDF_Writer.print_margin_right: 0.5
     print.printer_CutePDF_Writer.print_margin_top: 0.5
     print.printer_CutePDF_Writer.print_oddpages: true
     print.printer_CutePDF_Writer.print_orientation: 0
     print.printer_CutePDF_Writer.print_page_delay: 50
     print.printer_CutePDF_Writer.print_pagedelay: 500
     print.printer_CutePDF_Writer.print_paper_data: 1
     print.printer_CutePDF_Writer.print_paper_height: 11.00
     print.printer_CutePDF_Writer.print_paper_name:
     print.printer_CutePDF_Writer.print_paper_size_type: 0
     print.printer_CutePDF_Writer.print_paper_size_unit: 0
     print.printer_CutePDF_Writer.print_paper_width: 8.50
     print.printer_CutePDF_Writer.print_plex_name:
     print.printer_CutePDF_Writer.print_resolution: 271104
     print.printer_CutePDF_Writer.print_resolution_name:
     print.printer_CutePDF_Writer.print_reversed: false
     print.printer_CutePDF_Writer.print_scaling: 1.00
     print.printer_CutePDF_Writer.print_shrink_to_fit: false
     print.printer_CutePDF_Writer.print_to_file: false
     print.printer_CutePDF_Writer.print_unwriteable_margin_bottom: 0
     print.printer_CutePDF_Writer.print_unwriteable_margin_left: 0
     print.printer_CutePDF_Writer.print_unwriteable_margin_right: 0
     print.printer_CutePDF_Writer.print_unwriteable_margin_top: 0
     print.printer_Foxit_Reader_PDF_Printer.print_bgcolor: false
     print.printer_Foxit_Reader_PDF_Printer.print_bgimages: false
     print.printer_Foxit_Reader_PDF_Printer.print_duplex: 63104
     print.printer_Foxit_Reader_PDF_Printer.print_edge_bottom: 0
     print.printer_Foxit_Reader_PDF_Printer.print_edge_left: 0
     print.printer_Foxit_Reader_PDF_Printer.print_edge_right: 0
     print.printer_Foxit_Reader_PDF_Printer.print_edge_top: 0
     print.printer_Foxit_Reader_PDF_Printer.print_evenpages: true
     print.printer_Foxit_Reader_PDF_Printer.print_footercenter:
     print.printer_Foxit_Reader_PDF_Printer.print_footerleft: &PT
     print.printer_Foxit_Reader_PDF_Printer.print_footerright: &D
     print.printer_Foxit_Reader_PDF_Printer.print_headercenter:
     print.printer_Foxit_Reader_PDF_Printer.print_headerleft: &T
     print.printer_Foxit_Reader_PDF_Printer.print_headerright: &U
     print.printer_Foxit_Reader_PDF_Printer.print_in_color: true
     print.printer_Foxit_Reader_PDF_Printer.print_margin_bottom: 0.5
     print.printer_Foxit_Reader_PDF_Printer.print_margin_left: 0.5
     print.printer_Foxit_Reader_PDF_Printer.print_margin_right: 0.5
     print.printer_Foxit_Reader_PDF_Printer.print_margin_top: 0.5
     print.printer_Foxit_Reader_PDF_Printer.print_oddpages: true
     print.printer_Foxit_Reader_PDF_Printer.print_orientation: 0
     print.printer_Foxit_Reader_PDF_Printer.print_page_delay: 50
     print.printer_Foxit_Reader_PDF_Printer.print_paper_data: 1
     print.printer_Foxit_Reader_PDF_Printer.print_paper_height: 11.00
     print.printer_Foxit_Reader_PDF_Printer.print_paper_name:
     print.printer_Foxit_Reader_PDF_Printer.print_paper_size_type: 0
     print.printer_Foxit_Reader_PDF_Printer.print_paper_size_unit: 0
     print.printer_Foxit_Reader_PDF_Printer.print_paper_width: 8.50
     print.printer_Foxit_Reader_PDF_Printer.print_resolution: 271104
     print.printer_Foxit_Reader_PDF_Printer.print_reversed: false
     print.printer_Foxit_Reader_PDF_Printer.print_scaling: 1.00
     print.printer_Foxit_Reader_PDF_Printer.print_shrink_to_fit: false
     print.printer_Foxit_Reader_PDF_Printer.print_to_file: false
     print.printer_Foxit_Reader_PDF_Printer.print_unwriteable_margin_bottom: 0
     print.printer_Foxit_Reader_PDF_Printer.print_unwriteable_margin_left: 0
     print.printer_Foxit_Reader_PDF_Printer.print_unwriteable_margin_right: 0
     print.printer_Foxit_Reader_PDF_Printer.print_unwriteable_margin_top: 0
     print.printer_Generic_50C-1_Series_PS.print_bgcolor: false
     print.printer_Generic_50C-1_Series_PS.print_bgimages: false
     print.printer_Generic_50C-1_Series_PS.print_colorspace:
     print.printer_Generic_50C-1_Series_PS.print_command:
     print.printer_Generic_50C-1_Series_PS.print_downloadfonts: false
     print.printer_Generic_50C-1_Seri

Nothing jumps out there. Maybe someone else will see something.

FYI:Next time do not worry about all the printer info. We mainly just want to see server settings.

I do see that you have several addresses on this same server. Do you have an SMTP setting for each one with the corresponding usernames?