It sounds like you have a program that monitors changes in your settings.

Note: Some software, like Advanced SystemCare with Surfing Protection, can protect files in the Firefox profile folder against changes. If you have such software then check the settings or uninstall this software.

There is some malware that protects itself by discouraging you from removing it. Here's my suggested procedure for tracking down and cleaning up bad add-ons, hijackers, and ad injectors. I know it seems long, but it's not that bad.

(1) Open the Windows Control Panel, Uninstall a Program. After the list loads, click the "Installed on" column heading to group the infections, I mean, additions, by date. This can help in smoking out undisclosed bundle items that snuck in with some software you agreed to install. Be suspicious of everything you do not recognize/remember, as malware often uses important or innocent sounding names to discourage you from removing it. Take out as much trash as possible here.

(2) Open Firefox's Add-ons page using either:

• Ctrl+Shift+a
• "3-bar" menu button (or Tools menu) > Add-ons
• in the Windows "Run" dialog, type or paste
  firefox.exe "about:addons"

In the left column, click Plugins. Set nonessential and unrecognized plugins to "Never Activate".

In the left column, click Extensions. Then, if in doubt, disable (or Remove, if possible) unrecognized and unwanted extensions. Bear in mind that all extensions are optional, none come with Firefox, and you can learn more about them by checking their reviews on the Add-ons site.

Often a link will appear above at least one disabled extension to restart Firefox. You can complete your work on the tab and click one of the links as the last step.

Any improvement?

(3) You can search for remaining issues with the scanning/cleaning tools listed in our support article: Troubleshoot Firefox issues caused by malware. These on-demand scanners are free and take considerable time to run. If they finish quickly and especially if they require payment, you may have a serious infection. I suggest the specialized forums listed in the article in that case.

Success?

Can you attach a screenshot?

• http://en.wikipedia.org/wiki/Screenshot
• https://support.mozilla.org/kb/how-do-i-create-screenshot-my-problem

• Use a compressed image type like PNG or JPG to save the screenshot
• Make sure that you do not exceed the maximum size of 1 MB

Do a clean reinstall and delete the Firefox program folder before (re)installing a fresh copy of the current Firefox release.

• Download the Firefox installer and save the file to the desktop
  https://www.mozilla.org/en-US/firefox/all/

If possible uninstall your current Firefox version to cleanup the Windows registry and settings in security software.

• Do NOT remove "personal data" when you uninstall your current Firefox version, because this will remove all profile folders and you lose personal data like bookmarks and passwords including data in profiles created by other Firefox versions.

Remove the Firefox program folder before installing that newly downloaded copy of the Firefox installer.

• (32 bit Windows) "C:\Program Files\Mozilla Firefox\"
• (64 bit Windows) "C:\Program Files (x86)\Mozilla Firefox\"

• It is important to delete the Firefox program folder to remove all the files and make sure that there are no problems with files that were leftover after uninstalling.
• http://kb.mozillazine.org/Uninstalling_Firefox

Your bookmarks and other personal data are stored in the Firefox profile folder and won't be affected by an uninstall and (re)install, but make sure NOT to remove personal data when you uninstall Firefox as that will remove all Firefox profile folders and you lose your personal data.

If you keep having problems then create a new profile.

• http://kb.mozillazine.org/Profile_folder_-_Firefox
• http://kb.mozillazine.org/Profile_backup

• http://kb.mozillazine.org/Standard_diagnostic_-_Firefox#Clean_reinstall