Profile cannot be loaded and renaming the file doesn't work
I had a problem with Firefox not loading but at that time I was NOT getting the "Profile cannot be loaded" message. It just would NOT open. I deleted Firefox and reinstalled but now when I try to open it, I get the "Profile missing" notification. I've tried renaming the Profile file but it doesn't help.
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Try finding the profile https://support.mozilla.org/en-US/kb/profiles-where-firefox-stores-user-data and https://support.mozilla.org/en-US/kb/recover-lost-or-missing-bookmarks#w_determine-if-firefox-has-created-a-new-profile and https://support.mozilla.org/en-US/kb/profile-manager-create-and-remove-firefox-profiles and https://support.mozilla.org/en-US/kb/how-run-firefox-when-profile-missing-inaccessible
and last resort only https://support.mozilla.org/en-US/kb/refresh-firefox-reset-add-ons-and-settings
Please let us know if this solved your issue or if need further assistance.