Message: your thunderbird profile cannot be loaded. it may be missing or inaccessible

If you tell us what you did that caused the error, it may be easier to help you fix it. It's probably there.

I have same issue today. I did two things: First removed Waterfox using REVO Unstaller. REBOOTED

I might have had RATAIL malware so decided to install Charter Security Suite since was free with my account. Rebooted.

At this point is when I wanted to check my email. Got error. Reall need this fixed as I have years of email that I need. Thanks

ggrussell, your issue may be much different, as I am unaware of how Waterfox or the malware issue. I encourage doing a separate post to improve odds of someone familar to assist.

Ok Thanks