-no-remote option didn't work on firefox 12 windows 7 64 bit
After update firefox to lastest version -no-remote feature didn't work anymore. I use 2 profile for surfing. If i start one profile and start other, firefox said: "Close firefox, firefox already running but not responding. To open a new windows you must first close the exist process, or restart your systems."
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What is the exact command line that you use for both profiles?
You can also get that error if a profile with the specified profile name doesn't exist.
You can try to start via the Profile Manager (-no-remote -P) to see if it works if you select the profile.
i use both: -P "profilename" -no-remote and -p "profilename" -no-remote. I had create profilename already, and start firefox from shortcut: "C:\Program Files (x86)\Mozilla Firefox\firefox.exe" -P "profilename" -no-remote