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ADOBE FAILED TO CONNECT DDE SERVER

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After downloading PDF files from mail or web in Firefox browser, the file is not opening but instead it says "Adobe failed to connect DDE server". But, if I restart my laptop, the file will open normally. I have installed all the latest versions of firefox and adobe reader. If I try to open the same files from some other browsers, it is working fine. I am facing this issue only in Firefox browser

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I would recommend uninstalling it and reinstalling it from scratch. Other work around reported to be helpful: https://forums.adobe.com/thread/416414 and disabling protected mode.