After auto updating this morning, my entire profile was pretty much broken, no history, tabs, bookmarks, plus cookies and local storage seeminlyg disabled, strict browser privacy enabled. I was able to restore the profile from my TimeMachine backup to before the update and recover history/bookmarks etc, but now it claims the various databases are readonly/not accessable. My only viable solution has been to install Firefox 141 and copy my restored profile data into a new profile created by Firefox 141 (not Dev Edition). Firefox doesn't think the same DBs are read only. Running Dev Edition 142b1 against the same fresh profile generates the errors attached. NS_ERROR_FILE_ACCESS_DENIED suggests permissions, but I have double checked all those, but given Firefox runs these fine, this looks to be a bug in Dev Edition