If anyone is still experiencing this issue, we believe the fastest way to get things working again is: * Ensure your uBlock Origin filters are up to date (see the [https://github.com/gorhill/ublock/wiki/Dashboard:-Filter-lists#update-now uBlock Origin Documentation] for how to do this. * Close all YouTube tabs * In the Firefox hamburger menu go to Settings, then Privacy and Security and click on the Manage Data button. In the resulting dialog, search for youtube.com, select the row for site youtube.com and click "Remove Selected" * Opening a new tab with youtube.com should now work. If anyone follows these steps and still experiences the same symptoms, please let us know [https://bugzilla.mozilla.org/show_bug.cgi?id=1963511 here].