Please explain the problem in detail. What happens? Error messages?

When I open my browser every time, the bookmarks on the bookmark interface disappear. I don't know how to do with it,

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Go to that message, and use the Undo link to its right.

https://support.mozilla.org/en-US/kb/how-to-fix-preferences-wont-save

Note: Some software, like Advanced SystemCare with Surfing Protection, can protect files in the Firefox profile folder against changes. If you have such software then check the settings or uninstall this software.

You can check for problems with the places.sqlite database (bookmarks and history) in the Firefox profile folder.

• use "Verify Integrity" on the "Help -> Troubleshooting Information" (about:support) page
• https://addons.mozilla.org/firefox/addon/places-maintenance/

See also:

• http://kb.mozillazine.org/Locked_or_damaged_places.sqlite
• https://support.mozilla.org/en-US/kb/Bookmarks+not+saved#w_fix-the-bookmarks-file

If "Verify Integrity" on the "Help -> Troubleshooting Information" (about:support) page or Places Maintenance can't repair the places.sqlite database then remove all places.sqlite file(s) in the Firefox profile folder to make Firefox rebuild the places.sqlite database from the most recent JSON backup in the bookmarkbackups folder.

• keep a backup copy of places.sqlite in case a new places.sqlite database has to be created
• http://kb.mozillazine.org/Unable_to_process_the_backup_file_-_Firefox

You can use the button on the "Help -> Troubleshooting Information" (about:support) page to go to the current Firefox profile folder or use the about:profiles page.

• Help -> Troubleshooting Information -> Profile Directory:
  Windows: Show Folder; Linux: Open Directory; Mac: Show in Finder
• http://kb.mozillazine.org/Profile_folder_-_Firefox