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I check the pop-up blocker box in Options, but after a while I find it unchecked -- usually after I reopen the browser.
Firefox help said McAfee can change preferences, but when I clicked on the link it provided in response to that problem (the link said ``Pop-up Blocker), it didn't discuss the anti-virus issue. I don't know if McAfee is the problem, though. And the problem of finding the pop-up box unchecked has persisted through several Firefox software updates.