In order for us to better investigate this issue you need to add a little more non-personal information.

Please add the troubleshooting information to your post To find the Troubleshooting information:

• Open Help (or click on three-line-icon and select Help)
• Choose Troubleshooting Information
• Use the button Copy to clipboard to select all. Do not check box "Include account names"!
• Paste this in your post.

Please also add the result of these troubleshooting steps to your post

• Does Thunderbird work in TB Safe mode (see Thunderbird Safe Mode)?
• Do you use anti-virus and firewall software? What is the version?

Thanks Matt

 Application Basics

   Name: Thunderbird
   Version: 45.6.0
   User Agent: Mozilla/5.0 (Windows NT 10.0; WOW64; rv:45.0) Gecko/20100101 Thunderbird/45.6.0
   Profile Folder: Show Folder

             (Local drive)
   Application Build ID: 20161222195647
   Enabled Plugins: about:plugins
   Build Configuration: about:buildconfig
   Memory Use: about:memory

 Mail and News Accounts
   account2:
     INCOMING: account2, , (none) Local Folders, plain, passwordCleartext

   account8:
     INCOMING: account8, , (imap) mail.webplus.net:143, plain, passwordCleartext
     OUTGOING: , smtp.talktalk.net:587, alwaysSTARTTLS, passwordCleartext, true

   account9:
     INCOMING: account9, , (imap) mail.webplus.net:143, plain, passwordCleartext
     OUTGOING: , smtp.talktalk.net:587, alwaysSTARTTLS, passwordCleartext, true

   account10:
     INCOMING: account10, , (imap) imap.gmx.com:143, plain, passwordCleartext
     OUTGOING: , smtp.talktalk.net:587, alwaysSTARTTLS, passwordCleartext, true

   account12:
     INCOMING: account12, , (imap) imap.gmail.com:993, SSL, OAuth2
     OUTGOING: , smtp.talktalk.net:587, alwaysSTARTTLS, passwordCleartext, true

   account13:
     INCOMING: account13, , (imap) imap.gmail.com:993, SSL, OAuth2
     OUTGOING: , smtp.gmail.com:465, SSL, OAuth2, true

 Crash Reports

 Extensions
   Colour Folders, 1.1, true, colorfolders@fisheater.com
   Lightning, 4.7.6, true, {e2fda1a4-762b-4020-b5ad-a41df1933103}
   Manually sort folders, 1.1.1, true, tbsortfolders@xulforum.org

 Important Modified Preferences

   Name: Value

     browser.cache.disk.capacity: 358400
     browser.cache.disk.filesystem_reported: 1
     browser.cache.disk.smart_size_cached_value: 358400
     browser.cache.disk.smart_size.first_run: false
     browser.cache.disk.smart_size.use_old_max: false
     dom.apps.reset-permissions: true
     extensions.lastAppVersion: 45.6.0
     font.internaluseonly.changed: false
     font.name.monospace.el: Consolas
     font.name.monospace.tr: Consolas
     font.name.monospace.x-baltic: Consolas
     font.name.monospace.x-central-euro: Consolas
     font.name.monospace.x-cyrillic: Consolas
     font.name.monospace.x-unicode: Consolas
     font.name.monospace.x-western: Consolas
     font.name.sans-serif.el: Calibri
     font.name.sans-serif.tr: Calibri
     font.name.sans-serif.x-baltic: Calibri
     font.name.sans-serif.x-central-euro: Calibri
     font.name.sans-serif.x-cyrillic: Calibri
     font.name.sans-serif.x-unicode: Calibri
     font.name.serif.el: Cambria
     font.name.serif.tr: Cambria
     font.name.serif.x-baltic: Cambria
     font.name.serif.x-central-euro: Cambria
     font.name.serif.x-cyrillic: Cambria
     font.name.serif.x-unicode: Cambria
     font.name.serif.x-western: Cambria
     font.size.fixed.el: 14
     font.size.fixed.tr: 14
     font.size.fixed.x-baltic: 14
     font.size.fixed.x-central-euro: 14
     font.size.fixed.x-cyrillic: 14
     font.size.fixed.x-unicode: 14
     font.size.fixed.x-western: 14
     font.size.variable.el: 17
     font.size.variable.tr: 17
     font.size.variable.x-baltic: 17
     font.size.variable.x-central-euro: 17
     font.size.variable.x-cyrillic: 17
     font.size.variable.x-unicode: 17
     font.size.variable.x-western: 17
     gfx.crash-guard.glcontext.appVersion: 45.6.0
     gfx.crash-guard.glcontext.deviceID: 0x0f31
     gfx.crash-guard.glcontext.driverVersion: 10.18.10.4276
     gfx.crash-guard.glcontext.gfx.driver-init.direct3d11-angle: true
     gfx.crash-guard.glcontext.gfx.driver-init.webgl-angle: true
     gfx.crash-guard.glcontext.gfx.driver-init.webgl-angle-force-d3d11: false
     gfx.crash-guard.glcontext.gfx.driver-init.webgl-angle-force-warp: false
     gfx.crash-guard.glcontext.gfx.driver-init.webgl-angle-try-d3d11: true
     gfx.crash-guard.status.glcontext: 2
     gfx.direct3d.last_used_feature_level_idx: 0
     mail.openMessageBehavior.version: 1
     mail.winsearch.enable: true
     mail.winsearch.firstRunDone: true
     mail.winsearch.global_reindex_time: 1416186778
     mailnews.database.global.datastore.id: 4cd31792-db74-40a2-94f0-a8edf27af1e
     mailnews.database.global.views.global.columns: {"threadCol":{"visible":true,"ordinal":"1"},"flaggedCol":{"visible":true,"ordinal":"3"},"attachmentCol":{"visible":false…
     network.cookie.prefsMigrated: true
     network.predictor.cleaned-up: true
     places.database.lastMaintenance: 1483544177
     places.history.expiration.transient_current_max_pages: 104858
     plugin.importedState: true
     print.printer_EPSON_Stylus_SX200_Series.print_bgcolor: false
     print.printer_EPSON_Stylus_SX200_Series.print_bgimages: false
     print.printer_EPSON_Stylus_SX200_Series.print_evenpages: true
     print.printer_EPSON_Stylus_SX200_Series.print_footercenter:
     print.printer_EPSON_Stylus_SX200_Series.print_footerleft: &PT
     print.printer_EPSON_Stylus_SX200_Series.print_footerright: &D
     print.printer_EPSON_Stylus_SX200_Series.print_headercenter:
     print.printer_EPSON_Stylus_SX200_Series.print_headerleft: &T
     print.printer_EPSON_Stylus_SX200_Series.print_headerright: &U
     print.printer_EPSON_Stylus_SX200_Series.print_in_color: true
     print.printer_EPSON_Stylus_SX200_Series.print_margin_bottom: 0.5
     print.printer_EPSON_Stylus_SX200_Series.print_margin_left: 0.5
     print.printer_EPSON_Stylus_SX200_Series.print_margin_right: 0.5
     print.printer_EPSON_Stylus_SX200_Series.print_margin_top: 0.5
     print.printer_EPSON_Stylus_SX200_Series.print_oddpages: true
     print.printer_EPSON_Stylus_SX200_Series.print_orientation: 0
     print.printer_EPSON_Stylus_SX200_Series.print_reversed: false
     print.printer_EPSON_Stylus_SX200_Series.print_scaling: 1.00
     print.printer_EPSON_Stylus_SX200_Series.print_shrink_to_fit: true
     print.printer_XP-332_335_Series(Network).print_bgcolor: false
     print.printer_XP-332_335_Series(Network).print_bgimages: false
     print.printer_XP-332_335_Series(Network).print_duplex: -437918235
     print.printer_XP-332_335_Series(Network).print_edge_bottom: 0
     print.printer_XP-332_335_Series(Network).print_edge_left: 0
     print.printer_XP-332_335_Series(Network).print_edge_right: 0
     print.printer_XP-332_335_Series(Network).print_edge_top: 0
     print.printer_XP-332_335_Series(Network).print_evenpages: true
     print.printer_XP-332_335_Series(Network).print_footercenter:
     print.printer_XP-332_335_Series(Network).print_footerleft: &PT
     print.printer_XP-332_335_Series(Network).print_footerright: &D
     print.printer_XP-332_335_Series(Network).print_headercenter:
     print.printer_XP-332_335_Series(Network).print_headerleft: &T
     print.printer_XP-332_335_Series(Network).print_headerright: &U
     print.printer_XP-332_335_Series(Network).print_in_color: true
     print.printer_XP-332_335_Series(Network).print_margin_bottom: 0.5
     print.printer_XP-332_335_Series(Network).print_margin_left: 0.5
     print.printer_XP-332_335_Series(Network).print_margin_right: 0.5
     print.printer_XP-332_335_Series(Network).print_margin_top: 0.5
     print.printer_XP-332_335_Series(Network).print_oddpages: true
     print.printer_XP-332_335_Series(Network).print_orientation: 0
     print.printer_XP-332_335_Series(Network).print_page_delay: 50
     print.printer_XP-332_335_Series(Network).print_paper_data: 9
     print.printer_XP-332_335_Series(Network).print_paper_height: 11.00
     print.printer_XP-332_335_Series(Network).print_paper_name:
     print.printer_XP-332_335_Series(Network).print_paper_size_type: 0
     print.printer_XP-332_335_Series(Network).print_paper_size_unit: 1
     print.printer_XP-332_335_Series(Network).print_paper_width: 8.50
     print.printer_XP-332_335_Series(Network).print_resolution: -437918235
     print.printer_XP-332_335_Series(Network).print_reversed: false
     print.printer_XP-332_335_Series(Network).print_scaling: 1.00
     print.printer_XP-332_335_Series(Network).print_shrink_to_fit: true
     print.printer_XP-332_335_Series(Network).print_to_file: false
     print.printer_XP-332_335_Series(Network).print_unwriteable_margin_bottom: 0
     print.printer_XP-332_335_Series(Network).print_unwriteable_margin_left: 0
     print.printer_XP-332_335_Series(Network).print_unwriteable_margin_right: 0
     print.printer_XP-332_335_Series(Network).print_unwriteable_margin_top: 0
     privacy.sanitize.timeSpan: 0

 Graphics

     Adapter Description: Intel(R) HD Graphics
     Vendor ID: 0x8086
     Device ID: 0x0f31
     Adapter RAM: Unknown
     Adapter Drivers: igdumdim64 igd10iumd64 igd10iumd64 igdumdim32 igd10iumd32 igd10iumd32
     Driver Version: 10.18.10.4276
     Driver Date: 8-17-2015
     Direct2D Enabled: false
     DirectWrite Enabled: false (10.0.10586.633)
     ClearType Parameters: ClearType parameters not found
     WebGL Renderer: Google Inc. -- ANGLE (Intel(R) HD Graphics Direct3D11 vs_5_0 ps_5_0) -- OpenGL ES 2.0 (ANGLE 2.1.0.316930d51ea9)
     GPU Accelerated Windows: 0

     AzureCanvasBackend: skia
     AzureSkiaAccelerated: 0
     AzureFallbackCanvasBackend: cairo
     AzureContentBackend: cairo

 JavaScript

 Incremental GC: 1

 Accessibility

   Activated: 0
   Prevent Accessibility: 0

 Library Versions

     Expected minimum version
     Version in use

     NSPR
     4.12
     4.12

     NSS
     3.21.3 Basic ECC
     3.21.3 Basic ECC

     NSS Util
     3.21.3
     3.21.3

     NSS SSL
     3.21.3 Basic ECC
     3.21.3 Basic ECC

     NSS S/MIME
     3.21.3 Basic ECC
     3.21.3 Basic ECC

I have tried it in safe mode same results no connection and my Anti Virus is AVG Zen Build: 1.113.2.500020 + Malwarebytes Anti-Malware 2.2.1.1043 free version ok Matt!

some doozy issues here for sending, but you do not mention that.

Receiving.

First web plus.

They say here http://support.serif.com/kb/a554/how-to-use-your-webplus_net-email-address-with-other.aspx

First you'll need to collect the following information:

   Username (this is your email address)
   Password
   Incoming mail server* i.e. mail.yourdomainname.com
   Outgoing mail server* i.e. mail.yourdomainname.com

• If you've got the silver hosting package, your incoming and outgoing mail server will be mail.webplus.net.

Depending on how you want to send and receive your emails, you will need to choose an account type: POP3 or IMAP. Once you've decided which one you want to use, please make a note of the following port numbers:

   POP3: Incoming port 110, Outgoing port 25
   IMAP: Incoming port 143, Outgoing port 25

So accounts 8 and 9 need to have both their incoming and outgoing server information corrected in account settings.

Account 10 need to have it's incoming and outgoing settings corrected as per https://support.gmx.com/pop-imap/imap/server.html

Account 12 needs to have it's outgoing server corrected to use the same server settings as account 13, but not the same username. So an additional outgoing server will probably have to be created.

Incoming server setting are in server settings. Outgoing server settings are in outgoing server (SMTP) The outgoing server used by an account is specified in the general account information above server settings in the list. (you click the account name.)

Once all that is corrected, perhaps it will work, unless there is something else wrong, like AVG screwing up.

Well I just opened AVG to check that and it was stopping thunderbird from working allowed thunderbird and its started working again must have been after avg last updated so thanks Matt you put me on the right track didn't think of the antivirus blocking it cheers mate if Icould get you a drink I would thanks mate, Neil

I'm having the same problem trying to enter my google details on Thunderbird. I use Windows defender? The Google sign in box pops up but will not move on with the next prompt after entering my email address. Hence can't connect to gmail server.