First, let's backup your profile; Back up and restore information in Firefox profiles.{web link} I use an add-on that makes backups of my user profile, Just In Case. Unfortunately, it is not compatible with the current Firefox.

Every now and then, open the profile folder and create a copy of the current profile as is to another location on your hard drive. This way you will have a backup.

If you do this each day, you will not lose much data. This should be done with Firefox Closed.

Note: In case you need to restore from these backups, you may need to overwrite old or corrupted files.

wedge5 said

firefox keeps blanking all bookmarks every couple of months

Can you tell what happens at the time? What about the rest of the profile? settings, passwords . . . .